General Information

  • ID:  hor006685
  • Uniprot ID:  Q92106
  • Protein name:  Progonadoliberin-3
  • Gene name:  gnrh3
  • Organism:  Rutilus rutilus (Roach)
  • Family:  GnRH family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Rutilus (genus), Leuciscinae (subfamily), Leuciscidae (family), Cyprinoidei (suborder), Cypriniformes (order), Cypriniphysae (superorder), Otophysi, Ostariophysi (subcohort), Otomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence Information

  • Sequence:  QHWSYGWLPGGKRSVGEVEATIRMMDGGDTLLSIPADTPMEQLSPIHIMNEVDAEGFPLKEQRFPNRRGRM
  • Length:  71(24-94)
  • Propeptide:  MEWKGRVLVQLLMLVCVLEVSLCQHWSYGWLPGGKRSVGEVEATIRMMDGGDTLLSIPADTPMEQLSPIHIMNEVDAEGFPLKEQRFPNRRGRM
  • Signal peptide:  MEWKGRVLVQLLMLVCVLEVSLC
  • Modification:  T1 Pyrrolidone carboxylic acid;T10 Glycine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Stimulates the secretion of gonadotropins.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q92106-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006685_AF2.pdbhor006685_ESM.pdb

Physical Information

Mass: 928790 Formula: C351H550N102O105S5
Absent amino acids: C Common amino acids: G
pI: 5.64 Basic residues: 10
Polar residues: 18 Hydrophobic residues: 19
Hydrophobicity: -63.1 Boman Index: -14531
Half-Life / Aliphatic Index: 0.8 hour Aliphatic Index: 65.92
Instability Index: 4918.45 Extinction Coefficient cystines: 12490
Absorbance 280nm: 178.43

Literature

  • PubMed ID:  9460654
  • Title:  Isolation and characterisation of mRNA encoding the salmon- and chicken-II type gonadotrophin-releasing hormones in the teleost fish Rutilus rutilus (Cyprinidae).